PERBEDAAN KADAR ALBUMIN SEBELUM DAN SESUDAH TRANSFUSI ALBUMIN PADA PENYAKIT GINJAL KRONIK

Subiyanti, Titik, G1C 216136 (2017) PERBEDAAN KADAR ALBUMIN SEBELUM DAN SESUDAH TRANSFUSI ALBUMIN PADA PENYAKIT GINJAL KRONIK. Sarjana / Sarjana Terapan (S1/D4) thesis, ["eprint_fieldopt_institution_Universitas Muhammadiyah Semarang" not defined].

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Abstract

Pasien penyakit ginjal kronik kehilangan protein melalui urin dapat menyebabkan terjadinya penurunan kadar albumin serum atau hipoalbuminemia. Keluarnya albumin melalui urin karena peningkatan permeabilitas di tingkat glomerulus menyebabkan protein lolos ke dalam filtrat glomerulus. Keadaan kadar albumin dalam plasma menurun sampai mengalami hipoalbunemia berat, transfusi albumin menjadi salah satu pilihan tatalaksana yang telah dipakai selama lebih dari 60 tahun. Terapi albumin pasien penyakit ginjal kronik diberikan ketika pasien mengalami hipoalbuminemia dengan kadar albumin < 2,5g/dL Nilai rujukan kadar albumin orang dewasa 3,5 - 5,0 g/dl atau 5,2%- 8% dari protein total. Tujuan penelitian untuk mengetahui perbedaan kadar albumin sebelum dan sesudah transfusi albumin pada pasien penyakit ginjal kronik. Jenis penelitian adalah analitik dengan pendekatan cross sectional. Penelitian dilakukan di laboratorium RSUD Tugurejo Semarang pada bulan Mei-Juni 2017. Hasil penelitian menunjukkan kadar albumin sesudah mendapat transfusi albumin lebih tinggi dibanding sebelum transfusi albumin. Kenaikkan kadar albumin karena masuknya sediaan albumin 20% volume 100 ml yang mengandung 20 g albumin, dan pemberian albumin 5% meningkatkan albumin volume plasma hingga 80% dari volume yang diberikan. Selisih kadar albumin rata-rata 0,42 mg/dl atau 0,16%. Uji beda dengan Paired t Test menunjukkan hasil terdapat perbedaan yang bermakna pada kadar albumin. Kata kunci : kadar albumin, transfusi albumin Patients with chronic kidney disease are loss of protein through urine that can lead to a decrease in serum albumin level or hypoalbuminemia. The albumin releasethrough urine becauseof increased permeability at glomerular level which causes the protein to pass into the glomerular filtrate. The albumin level state in the plasma is decreases to experience severe hypoalbunemia, albumin transfusion becomes one of the treatment option that have been used for more than 60 years. Albumin therapy for patients with chronic kidney disease is given when the patient has hypoalbuminemia with albumin level <2.5 g/dL. The research goalis to know the difference of albumin level before and after albumin transfusion on patients with chronic kidney disease. The researchtype is analytic with cross sectional approach. The research was conducted in the laboratory RSUD Tugurejo Semarang on May-June 2017. The research result showed that albumin level after receiving albumin transfusion was higher than before albumintransfusion. Increased albumin level because of 20% albumininclusion preparation 100 ml of volumewhich contain 20 g of albumin, and 5% of albumin givingthat increased plasma volume albumin by up to 80% of the given volume. The difference in albumin level was averaged 0.42 mg/dl or 0.16%. Different test with Paired t Test showed result that there was significant difference on albumin level. Keywords: albumin level, albumin transfusion

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