HUBUNGAN KADAR BILIRUBIN TOTAL DAN BILIRUBIN DIREK PADA PENDERITA HIV BEDASARKAN LAMA MENDERITA

Nafi’ah, Siti, G1C013030 (2017) HUBUNGAN KADAR BILIRUBIN TOTAL DAN BILIRUBIN DIREK PADA PENDERITA HIV BEDASARKAN LAMA MENDERITA. Sarjana / Sarjana Terapan (S1/D4) thesis, ["eprint_fieldopt_institution_Universitas Muhammadiyah Semarang" not defined].

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Abstract

Human Immunodeficienty Virus (HIV) merupakan salah satu virus yang menyerang sel darah putih di dalam tubuh manusia sebagai penyebab penyakit Acquired Immunodeficienty Virus (AIDS). Penyakit HIV dimulai dengan infeksi akut yang tidak dapat diatasi oleh respon imun adaptif, dan berlanjut menjadi infeksi jaringan limfoid perifer yang kronik dan progresif, sehingga penderita HIV dapat memperlihatkan gejala klinis sebagai dampak dari virus yang terlihat dalam beberapa bulan sampai beberapa tahun setelah terinfeksi. Akibatnya organ dalam tubuh dapat terganggu, salah satunya organ hati karena dapat menyebabkan infeksi kronis (menahun), yang berarti infeksi tidak hilang dan lambat laun dapat mengarahkan pada gangguan hati berat. Gangguan hati dapat memicu peningkatan kadar bilirubin karena terjadi kesulitan dalam pengangkutan dan konjugasi bilirubin yang menyebabkan bilirubin tidak sempurna dikeluarkan. Bilirubin diperiksa sebagai bilirubin total dan bilirubin direk.Tujuan menganalisis kadar bilirubin total dan Bilirubin direk bedasarkan lama menderita HIV. Jenis penelitian ini adalah penelitian analitik dengan pendekatan cross sectional. Penelitian ini dilakukan terhadap 27 responden HIV yang mengikuti KDS dari total populasi yang memenuhi kriteria inkulsi dan eksklusi di BALKESMAS kota semarang. Analisis statistik menggunakan uji r person. Hasil uji menunjukkan tidak adanya hubungan lama menderita HIV dengan kadar bilirubin total nilai p> 0,05 dan didapat adanya hubungan lama menderita HIV dengan bilirubin direk p<0,05. Kata kunci : HIV, Bilirubin Total, Bilirubin Direk. Human Immunodeficienty Virus (HIV) is one of the viruses that attack white blood cells in the human body as the cause of Acquired immunodeficienty virus (AIDS). HIV disease is begun with an acute infection that can not be resolved by the adaptive immune response, and continued to become a chronic and progressive lymphoid peripheral tissue infection, so that HIV patients can show clinical symptoms as a result of the virus seen within months to years after infection. As a result, the organs in the body can be disrupted, one of which the liver because it can cause chronic infection, which means that the infection does not disappear and gradually can lead to severe liver disorders. Liver disorders can trigger an increase in bilirubin levels because the difficulties in transporting and bilirubin conjugation which can cause imperfect bilirubin to be excreted. Bilirubin is examined as total bilirubin and direct bilirubin. The objective was to analyze total bilirubin levels and direct bilirubin base on HIV. The type of this research was analytic research with cross sectional approach. This study was conducted to 27 HIV respondents who follow KDS from the total population who met the criteria of inclusion and exclusion in BALKESMAS Semarang City. Statistical analysis used r person test. The test result showed that there was no correlation between long-terms HIV suffered and the amount of total bilirubin with p value >0.05, and found that there was a correlation between long-term HIV suffered and the amount of direct bilirubin with the p value < 0.05. Keywords : HIV, Bilirubin Total, Bilirubin Direk.

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