PERBEDAAN HITUNG JUMLAH NEUTROFIL ABSOLUT SEBELUM DAN SESUDAH PENGOBATAN OAT FASE AWAL PADA PENDERITA TBC DI BALKESMAS SEMARANG

Toisuta, Widia Astuti, G1C216151 (2017) PERBEDAAN HITUNG JUMLAH NEUTROFIL ABSOLUT SEBELUM DAN SESUDAH PENGOBATAN OAT FASE AWAL PADA PENDERITA TBC DI BALKESMAS SEMARANG. Sarjana / Sarjana Terapan (S1/D4) thesis, ["eprint_fieldopt_institution_Universitas Muhammadiyah Semarang" not defined].

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Abstract

Penyakit TBC menyebabkan peningkatan leukosit terutama pada jajaran granulapoetik, salah satunya adalah neutrofil yang berperan dalam perlawanan terhadap infeksi yang menyerang tubuh. Penyakit ini dapat disembuhkan dengan pemberian paket obat anti tuberkulosis (OAT) secara teratur selama 6 bulan yang fungsinya membunuh populasi kuman, menekan pertumbuhan kuman dan meningkatkan fungsi fagosi tterhadap kuman. Tujuan penelitian untuk mengetahui perbedaan hitung jumlah neutrophil absolut (ANC) sebelum dan sesudah pengobatan OAT fase awal pengobatan TBC. Jenis penelitian ini adalah penelitian observational analitik. Sampel diambil dengan teknik sampel jenuh sebanyak 24 pasien TBC dari keseluruhan pasien TBC di Balkesmas Semarang. Pengambilan dan pemeriksaan sampel ANC dibagi 2 tahap yaitu sebelum pasien mendapatkan pengobatan dan sesudah mendapatkan pengobatan OAT pada fase awal. Hasil pemeriksaan ANC sebelum mendapatkan pengobatan OAT menunjukkan rata-rata 7.576/mm3, sedangkan rata-rata sesudah mendapatkan pengobatan OAT adalah 4.648/mm3 dengan selisih sebesar 2.928/mm3. Hal ini menunjukkan bahwa hasil pemeriksaan ANC sebelum pengobatan OAT lebih tinggi dibandingkan sesudah pengobatan OAT. Hasil uji statistic paired t test menunjukkan adanya perbedaan yang signifikan. Hasil ANC sebelum dan sesudah pengobatan OAT (p = 0,000 < α = 0,05). Kata kunci : Sebelum dan sesudah OAT, Hitung jumlah neutrofil absolut, TBC TB disease causes increased leukocytes, especially in the granulapoetik range, one of which is a neutrophil that plays a role in resistance to infections that attack the body. This disease can be cured by regular anti-tuberculosis drug (OAT) packs for 6 months whose function kills the germ population, suppresses the growth of germs and enhances phagocyte function against germs. The objective of the study was to determine the difference in the number of absolute neutrophils (ANC) before and after the initial treatment of OAT treatment. This type of research is observational analytic research. Samples were taken with saturated sample technique as many as 24 tuberculosis patients from whole TB patient in Balkesmas, Semarang. The sampling and examination of ANC samples is divided into 2 stages ie before the patient gets treatment and after the OAT treatment in the intensive phase. ANC results before getting OAT treatment showed an average of 7.576 / mm3, while the mean after receiving OAT treatment was 4,648 / mm3 with a difference of 2,928 / mm3. This suggests that ANC examination results prior to OAT treatment were higher than after treatment. The result of paired t test statistic showed significant difference of ANC result before and after OAT treatment (p = 0,000 <α = 0,05). Keywords: Before and after OAT Trearment, Absolut Neutrophil Count, Tuberculosis

Item Type: Thesis (Sarjana / Sarjana Terapan (S1/D4) )
Contributors Thesis: 220/D4Ana/II/2018
Subjects: R Medicine > Health Analyst
Divisions: Faculty of Nursing and Health > D4 Health Analyst
Depositing User: perpus unimus
URI: http://repository.unimus.ac.id/id/eprint/1160

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